IgE Class Antibody Therapeutics for Cancer (On Demand)

Monoclonal IgE antibodies targeting tumor-associated antigens may mediate potent immune-activating functions in tissues, resulting in anti-tumor activity. Dr. Bax will present in vitro and in vivo functions of two anti-cancer IgEs, associations with monocyte/macrophage polarisation, macrophage infiltration, and enriched pro-inflammatory signatures within tumors, the absence of preliminary evidence of type 1 hypersensitivity, and key outcomes of the first-in-class Phase 1 clinical trial; together supporting the potential of IgE-based cancer immunotherapies.

Seminar Information
Date Presented:
January 23, 2024 11:00 AM Eastern
Length:
1 hour
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IgE Class Antibody Therapeutics for Cancer (On Demand)

Monoclonal IgE antibodies targeting tumor-associated antigens may mediate potent immune-activating functions in tissues, resulting in anti-tumor activity. Dr. Bax will present in vitro and in vivo functions of two anti-cancer IgEs, associations with monocyte/macrophage polarisation, macrophage infiltration, and enriched pro-inflammatory signatures within tumors, the absence of preliminary evidence of type 1 hypersensitivity, and key outcomes of the first-in-class Phase 1 clinical trial; together supporting the potential of IgE-based cancer immunotherapies.

Speaker Information
Heather Bax  [ view bio ]
Individual topic purchase: Selected