#30 How Specific are Antibody Drugs? Revealing insights from a new generation of specificity assays

Limitations of conventional specificity tools have contributed to undetected polyspecificity in antibody drugs. We performed a systematic specificity analysis of preclinical and clinical antibodies and identified a surprisingly high rate of off-target binding throughout the industry, with up to one third of antibody drugs displaying off-target binding. Our findings across different phases of drug development suggest polyspecificity is a major source of drug attrition, and better tools could help to improve drug approvals and patient safety.

In this webinar, we will discuss the emergence of cell-based protein arrays as an alternative and improved technology to evaluate antibody specificity.

Key takeaways:

  • Cell-based protein arrays, including Integral Molecular’s Membrane Proteome Array™ (MPA), enable precise assessment of binding interactions
  • The MPA identified off-target binding interactions that were missed in tissue cross-reactivity studies
  • Early detection of off-target antibody binding can mitigate drug toxicity and attrition

 

 

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Start Time:
February 27, 2025 11:00 AM Eastern
10:00 AM Central, 9:00 AM Mountain, 8:00 AM Pacific
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1 hour
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4 days, 22 hours
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#30 How Specific are Antibody Drugs? Revealing insights from a new generation of specificity assays

Limitations of conventional specificity tools have contributed to undetected polyspecificity in antibody drugs. We performed a systematic specificity analysis of preclinical and clinical antibodies and identified a surprisingly high rate of off-target binding throughout the industry, with up to one third of antibody drugs displaying off-target binding. Our findings across different phases of drug development suggest polyspecificity is a major source of drug attrition, and better tools could help to improve drug approvals and patient safety.

In this webinar, we will discuss the emergence of cell-based protein arrays as an alternative and improved technology to evaluate antibody specificity.

Key takeaways:

  • Cell-based protein arrays, including Integral Molecular’s Membrane Proteome Array™ (MPA), enable precise assessment of binding interactions
  • The MPA identified off-target binding interactions that were missed in tissue cross-reactivity studies
  • Early detection of off-target antibody binding can mitigate drug toxicity and attrition
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